Popular American YouTuber Keenan Cahill died Thursday at the age of 27, his family told several American media.

The one who suffered from Maroteaux-Lamy disease, or type VI mucopolysaccharidosis, indicated on his social networks that he underwent open-heart surgery on December 15.

Mucopolysaccharidosis type VI is a rare genetic disease caused by the abnormal buildup of compounds called glycoaminoglycans in body cells, according to Orpha.net.

This buildup usually results in bone abnormalities, short stature, deafness, and heart damage.

Keenan Cahill became an internet celebrity in the early 2010s when he posted lip-synced videos.

Many celebrities, such as Katy Perry, Jennifer Aniston, 50 Cent or Justin Bieber have appeared in his videos over time. Videos that have accumulated more than 500 million views.