Madrid, August 1, 2023.
The oldest person whose age has been verified until 2021 was Jeanne Calment from France, who lived to be 122 years old and, in the world, around a million people are over 100 years old, especially in the so-called "blue zones".
Currently there are large investment projects promoted by Jef Bezzos, Elon Musk, Peter Thiel, Larry Ellison, among others, aimed at discovering the magic formula that "rejuvenates us" and reverses the multiple mechanisms of aging. In this sense, the doctor Manuel de la Peña, academic, professor of cardiology and President of the European Institute of Health and Social Welfare, highlights that the keys to longevity are "good hormone replacement therapy together with a heart-healthy diet, adequate control of factors cardiovascular risk such as arterial hypertension (ideally a maximum of 130/80), LDL cholesterol (less than 70), a blood level of lipoprotein (a) less than 50 and good control of overweight-obesity-diabetes to slow the process of arteriosclerosis Taking care of the microbiome, stress control, restful sleep, physical exercise, stem cell treatments (and cell reprogramming) and blood changes (plasma replacement), which all contribute to extending life until , even 120 years". In fact, he points out that from the age of 40 there is a hormonal decline that causes aging. Hormone replacement therapy, such as testosterone, estradiol and progesterone, among others, allow the hormonal balance to be restored. Dr. De la Peña adds that "longevity is determined, on the one hand, by 20,000 genes and, on the other, by epigenetics, that is, life habits (which influence the expression of genes). It is essential to know our human genome to know the genetic predisposition we have inherited to suffer certain diseases. There are genes that influence longevity, such as the Methuselah gene, but the expression of the genes is influenced by the epigenome, that is, our ability to influence the triggering factors such as bad habits Eat a healthy diet, avoid chronic stress, avoid toxic substances, avoid emotional conflicts, perform physical exercise, control high blood pressure and keep the most atherogenic fractions of LDL cholesterol, Lp(a), low, which are factors that decisively influence gene expression". On the other hand, he continues stating that multiple studies on "telomerase treatments" which is the enzyme that influences the lengthening of telomeres, which are what determine longevity. The more telomere lengthening, the longer you live. For comparison, chromosomes are like shoelaces and telomeres are like the little plastic you see on the ends of shoelaces. The longer the better, but with use they wear out and shorten. Studies are also being carried out with Klotho, a substance that is secreted by the kidney and that influences the delay of aging. Renal failure can reduce the production of Klotho by up to 90%. Dr. De la Peña has pointed out that "change of blood is key to longevity and, in fact, there are studies that have shown that when the old rats their blood plasma by that of young rats, it is observed how they run faster to look for food". The colloquially called blood changes are performed in certain hospitals and are scientifically called therapeutic apheresis procedures, the most common being plasmapheresis and immunoadsorption, which are used to treat numerous pathologies with great clinical results, following the American clinical guidelines for therapeutic apheresis. On the other hand, he points out that a balanced and healthy diet should include foods such as extra virgin olive oil, nuts (a handful of nuts daily), fruits, vegetables, whole grains, all kinds of fish, lean proteins and healthy fats. That is, follow an eating pattern focused on more plant foods and less animal fat to stay healthy. In addition, the diet should restrict processed foods, refined sugars, salt and trans fats that can have a negative impact on health and longevity. In short, avoid ultra-processed foods and eat organic foods, combined with intermittent fasting and caloric restriction. Regular physical exercise also has a positive impact on longevity. Exercise helps maintain a healthy weight, reduces the risk of chronic disease, and helps maintain muscle strength and flexibility, which can be especially important as you age. One option is to sign up for a dance school. The European Institute of Health and Social Welfare is an independent institution, where Nobel Prize winners, ministers of different political signs and members of the European Parliament, among others, have participated.
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