More than 290,000 more deaths, 67 million new diseases in next four years: A study predicts serious setbacks in fight against malaria. This was due to cutbacks in US budget that had come into force in May, writes London researchers in journal PLOS Medicine (Winskill et al., 2017). The resolutions of US Congress foresee that 2018 will be budget of President's Malaria Initiative (PMI) by 44 percent less. This threatens successes of recent years.

Most recently, death rate of malaria sufferers has fallen sharply. The researchers are also writing thanks to PMI, which has saved nearly one million lives since its foundation in 2005. The efforts of malaria initiative have reduced mortality rate of children under five years south of Sahara by one-sixth. An estimated 185 million cases of malaria have been prevented. PMI is currently active in 24 countries.

From 2013 to 2015 initiative had a total of almost 1.7 billion dollars available, researchers wrote. If it continues to be supported to this extent, a furr 690,000 lives could be preserved until 2020 and 162 million diseases could be prevented. But US government and Congress have or plans.

Although US President Donald Trump praised initiative's successes in September, US development Agency, USAID, also announced that it would extend its activities to or countries. But even May budget proposal was to cut money for PMI by almost half to 424 million US dollars compared to 2017. Such plans were adopted by Congress at end of October.

Malaria malaria: infection and immunity

For decades, vaccines against dangerous malaria tropica have been researched, with moderate success – because pathogen is treacherous. Plasmodium falciparum passes through several stages: parasite enters blood of human being through a sting of Anopheles mosquito , moves into liver and falls into red blood cells. Now he evokes symptoms, especially high fever.

The pathogen constantly changes its appearance during Blood stage ("Antigen variation"): disguised with ever new surface proteins, he fools immune system.

Very few people have innate immunity against malaria. Partial immunity is common in malaria areas. Only small children are seriously ill. Adults rarely experience dangerous complications; of many already-existing malaria episodes, your body knows enough antigen variants to control pathogen in blood.

With vaccines, scientists are trying to achieve this condition more quickly, prevent transmission or protect against infection.

The epidemiology of Peter Winskill of Imperial College and his colleagues have calculated what cutbacks for practical work in fight against malaria mean. However, your prognosis is only one model. They calculated how effective various protective measures are currently being financed with US subsidies in 19 African states and wider Mekong region. These include protection nets, combination rapy with plant substance Artemisinin or use of insecticides in living spaces.

"Our results are a conservative estimate because y do not even take into account entire effect of activities in PMI context," authors write. The money would, for example, relieve burden on local health authorities who would orwise have to take care of malaria. It is very important to continue to support countries that are seriously affected. Orwise, previous successes would be undone.

Date Of Update: 22 November 2017, 12:03